Evaluation of Activity Limitation in Patients with Idiopathic Pulmonary Fibrosis Grouped According t

OBJECTIVE:

To investigate relationships between Medical Research Council (MRC) dyspnea grade and peripheral muscle force, activities of daily living (ADL) performance, health status, lung function and exercise capacity in subjects with idiopathic pulmonary fibrosis (IPF).

DESIGN:

Prospective cross-sectional observational study.

SETTING:

University hospital, Japan PARTICIPANTS: Sixty-five subjects with IPF (46 males) in a stable clinical state with mean age 68 years (SD 7y).

INTERVENTIONS:

Not applicable.

MAIN OUTCOME MEASURES:

Right ventricular systolic pressure (RVSP) via transthoracic echocardiography, pulmonary function, isometric quadriceps force (QF) and handgrip force (HF), 6-minute walk distance (6MWD), ADL score, and health status (SF-36) were assessed, and compared between subjects grouped according to MRC grade.

RESULTS:

Sixteen, 17, 17 and 15 subjects were in MRC grade 2, 3, 4, and 5 respectively. RVSP, pulmonary function, QF, HF, 6MWD, ADL and SF-36 scores decreased with increasing MRC grade (all p<0.001). All measures were lower (p<0.05) in grade 4 and 5 compared to grade 2 and 3 subjects. Strong associations were found between MRC grade and 6MWD (rho=-0.89, p=0.001) and ADL score (rho=-0.82, p=0.001). MRC grade was also associated with RVSP, pulmonary function, QF and HF (all rho≥0.56, p=0.001).

CONCLUSIONS:

The MRC dyspnea scale provides a simple and useful method of categorizing individuals with IPF with respect to their activity limitation and may assist in understanding the impact of IPF on an individual.

Bigliografia :

Fonti :

ven 14 marzo 2014
VEDI ANCHE
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