A Comparison of Health-Related Quality of Life in Idiopathic Pulmonary Fibrosis and Chronic Hypersen
Patients with interstitial lung disease (ILD) have poor health-related quality of life (HRQL). However, whether HRQL differs among different subtypes of ILD is unclear. The aim of this study was to determine whether HRQL was different among patients with idiopathic pulmonary fibrosis (IPF) and chronic hypersensitivity pneumonitis (CHP).
We identified patients from an ongoing longitudinal cohort of ILD patients. HRQL was assessed using the SF-36v2 medical outcomes form. Regression analysis was used to determine the association between clinical co-variates and HRQL, primarily the physical component summary (PCS) and mental component summary (MCS) score. A multivariate regression model was created to identify potential co-variates that could help explain the association between the ILD subtype and HRQL.
IPF patients (n=102) were older, more likely to be men, and to have smoked. Pulmonary function was similar between the groups. The CHP patients (n=69) had worse HRQL across all eight domains of the SF-36, as well as the PCS and MCS, compared to IPF (p-value <0.01-0.09). This pattern remained after controlling for age and pulmonary function (p-value <0.01-0.02). Co-variates explaining part of the relationship between disease subtype and PCS score included severity of dyspnea (p-value <0.01) and fatigue (p-value 0.01). Co-variates explaining part of the relationship between disease subtype and MCS score included severity of dyspnea (p-value <0.01), female sex (p-value 0.02), and fatigue (p-value 0.02).
HRQL is worse in CHP compared to IPF. HRQL differences between ILD subtypes are explained in part by differences in gender, dyspnea, and fatigue.